Vandetanib (100 mg) in patients with locally advanced or metastatic hereditary medullary thyroid cancer.

ABSTRACT:

Purpose

Vandetanib is a once-daily oral inhibitor of vascular endothelial growth factor receptor-2 and epidermal growth factor receptor tyrosine kinases that also inhibits rearranged during transfection kinase activity. Vandetanib (300 mg/d) has previously demonstrated antitumor activity in patients with advanced hereditary medullary thyroid cancer (MTC). This study investigated the efficacy and safety of 100 mg/d vandetanib in patients with advanced hereditary MTC.

Patients and methods

Eligible patients with unresectable, measurable, locally advanced, or metastatic hereditary MTC received 100 mg/d vandetanib. Upon disease progression, eligible patients could enter postprogression treatment with 300 mg/d vandetanib until a withdrawal criterion was met. The primary objective

SUBMITTER: Robinson BG 

PROVIDER: S-EPMC2902067 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature