The effects of intermittent, CD4-guided antiretroviral therapy on body composition and metabolic parameters.

ABSTRACT:

Objective

To assess the effects of decreased antiretroviral therapy exposure on body fat and metabolic parameters.

Design

Substudy of the Strategies for Management of Anti-Retroviral Therapy study, in which participants were randomized to intermittent CD4-guided [Drug Conservation (DC) group] or to continuous [Viral Suppression (VS) group] antiretroviral therapy.

Methods

Participants at 33 sites were coenrolled in the Strategies for Management of Anti-Retroviral Therapy Body Composition substudy. Regional fat was assessed annually by whole-body dual-energy X-ray absorptiometry and abdominal computed tomography. Fasting metabolic parameters were assessed at months 4, 8, and annually. Treatment groups were compared for changes in fat and metabolic markers using longitud

SUBMITTER: Martinez E 

PROVIDER: S-EPMC2902280 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature