Comparative analysis of cis-regulation following stroke and seizures in subspaces of conserved eigensystems.

ABSTRACT:

Background

It is often desirable to separate effects of different regulators on gene expression, or to identify effects of the same regulator across several systems. Here, we focus on the rat brain following stroke or seizures, and demonstrate how the two tasks can be approached simultaneously.

Results

We applied SVD to time-series gene expression datasets from the rat experimental models of stroke and seizures. We demonstrate conservation of two eigensystems, reflecting inflammation and/or apoptosis (eigensystem 2) and neuronal synaptic activity (eigensystem 3), between the stroke and seizures. We analyzed cis-regulation of gene expression in the subspaces of the conserved eigensystems. Bayesian networks analysis was performed separately for either experimental model, with

SUBMITTER: Dabrowski M 

PROVIDER: S-EPMC2902439 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature