AlignMiner: a Web-based tool for detection of divergent regions in multiple sequence alignments of conserved sequences.

ABSTRACT:

Background

Multiple sequence alignments are used to study gene or protein function, phylogenetic relations, genome evolution hypotheses and even gene polymorphisms. Virtually without exception, all available tools focus on conserved segments or residues. Small divergent regions, however, are biologically important for specific quantitative polymerase chain reaction, genotyping, molecular markers and preparation of specific antibodies, and yet have received little attention. As a consequence, they must be selected empirically by the researcher. AlignMiner has been developed to fill this gap in bioinformatic analyses.

Results

AlignMiner is a Web-based application for detection of conserved and divergent regions in alignments of conserved sequences, focusing particularly on div

SUBMITTER: Guerrero D 

PROVIDER: S-EPMC2902484 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature