Diagnosis of partial body radiation exposure in mice using peripheral blood gene expression profiles.

ABSTRACT: In the event of a terrorist-mediated attack in the United States using radiological or improvised nuclear weapons, it is expected that hundreds of thousands of people could be exposed to life-threatening levels of ionizing radiation. We have recently shown that genome-wide expression analysis of the peripheral blood (PB) can generate gene expression profiles that can predict radiation exposure and distinguish the dose level of exposure following total body irradiation (TBI). However, in the event a radiation-mass casualty scenario, many victims will have heterogeneous exposure due to partial shielding and it is unknown whether PB gene expression profiles would be useful in predicting the status of partially irradiated individuals. Here, we identified gene expression profiles in the PB that

SUBMITTER: Meadows SK 

PROVIDER: S-EPMC2902517 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature