Detection of celiac disease and lymphocytic enteropathy by parallel serology and histopathology in a population-based study.

ABSTRACT:

Background & aims

Although serologic analysis is used in diagnosis of celiac disease, histopathology is considered most reliable. We performed a prospective study to determine the clinical, pathologic, and serologic spectrum of celiac disease in a general population (Kalixanda study).

Methods

A random sample of an adult general population (n = 1000) was analyzed by upper endoscopy, duodenal biopsy, and serologic analysis of tissue transglutaminase (tTg) levels; endomysial antibody (EMA) levels were analyzed in samples that were tTg+. The cut off values for diagnosis of celiac disease were villous atrophy with 40 intraepithelial lymphocytes (IELs)/100 enterocytes (ECs).

Results

Samples from 33 subjects were tTg+, and 16 were EMA+. Histologic analysis identified 7 of 10

SUBMITTER: Walker MM 

PROVIDER: S-EPMC2902605 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature