Regulation of lysine biosynthesis and transport genes in bacteria: yet another RNA riboswitch?

ABSTRACT: Comparative analysis of genes, operons and regulatory elements was applied to the lysine biosynthetic pathway in available bacterial genomes. We report identification of a lysine-specific RNA element, named the LYS element, in the regulatory regions of bacterial genes involved in biosynthesis and transport of lysine. Similarly to the previously described RNA regulatory elements for three vitamins (riboflavin, thiamin and cobalamin), purine and methionine regulons, this regulatory RNA structure is highly conserved on the sequence and structural levels. The LYS element includes regions of lysine-constitutive mutations previously identified in Escherichia coli and Bacillus subtilis. A possible mechanism of the lysine-specific riboswitch is similar to the previously defined mechanisms for the

SUBMITTER: Rodionov DA 

PROVIDER: S-EPMC290268 | biostudies-literature | 2003 Dec

REPOSITORIES: biostudies-literature