Progressive 3q amplification consistently targets SOX2 in preinvasive squamous lung cancer.

ABSTRACT:

Rationale

Amplification of distal 3q is the most common genomic aberration in squamous lung cancer (SQC). SQC develops in a multistage progression from normal bronchial epithelium through dysplasia to invasive disease. Identifying the key driver events in the early pathogenesis of SQC will facilitate the search for predictive molecular biomarkers and the identification of novel molecular targets for chemoprevention and therapeutic strategies. For technical reasons, previous attempts to analyze 3q amplification in preinvasive lesions have focused on small numbers of predetermined candidate loci rather than an unbiased survey of copy-number variation.

Objectives

To perform a detailed analysis of the 3q amplicon in bronchial dysplasia of different histological grades.

Method

SUBMITTER: McCaughan F 

PROVIDER: S-EPMC2902760 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature