Gene expression-based prognostic signatures in lung cancer: ready for clinical use?

ABSTRACT: A substantial number of studies have reported the development of gene expression-based prognostic signatures for lung cancer. The ultimate aim of such studies should be the development of well-validated clinically useful prognostic signatures that improve therapeutic decision making beyond current practice standards. We critically reviewed published studies reporting the development of gene expression-based prognostic signatures for non-small cell lung cancer to assess the progress made toward this objective. Studies published between January 1, 2002, and February 28, 2009, were identified through a PubMed search. Following hand-screening of abstracts of the identified articles, 16 were selected as relevant. Those publications were evaluated in detail for appropriateness of the study desig

SUBMITTER: Subramanian J 

PROVIDER: S-EPMC2902824 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature