The intrinsic complement regulator decay-accelerating factor modulates the biological response to vascular injury.

ABSTRACT:

Objective

To investigate whether the presence of decay-accelerating factor (or CD55), an intrinsic complement regulator, protects against the development of vascular disease, given that complement activation can affect leukocytes and platelets.

Methods and results

Leukocyte-platelet complexes are critical for the initiation and progression of atherosclerosis and restenosis; however, the mechanism by which these processes promote vascular injury is incompletely defined. We performed femoral artery wire injury in Daf1(-/-) mice and their wild-type controls. Leukocyte accumulation, cellular proliferation, and neointimal thickening were enhanced in Daf1(-/-) mice versus wild-type mice. Deficiency of either the C3a or the C5a receptor, respectively, reversed the increased vascula

SUBMITTER: Sakuma M 

PROVIDER: S-EPMC2903214 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature