Integrated molecular genetic profiling of pediatric high-grade gliomas reveals key differences with the adult disease.

ABSTRACT:

Purpose

To define copy number alterations and gene expression signatures underlying pediatric high-grade glioma (HGG).

Patients and methods

We conducted a high-resolution analysis of genomic imbalances in 78 de novo pediatric HGGs, including seven diffuse intrinsic pontine gliomas, and 10 HGGs arising in children who received cranial irradiation for a previous cancer using single nucleotide polymorphism microarray analysis. Gene expression was analyzed with gene expression microarrays for 53 tumors. Results were compared with publicly available data from adult tumors.

Results

Significant differences in copy number alterations distinguish childhood and adult glioblastoma. PDGFRA was the predominant target of focal amplification in childhood HGG, including diffuse intri

SUBMITTER: Paugh BS 

PROVIDER: S-EPMC2903336 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature