MAPK-activated protein kinase-2 in cardiac hypertrophy and cyclooxygenase-2 regulation in heart.

ABSTRACT:

Rationale

Activation of p38 mitogen-activated protein kinase (MAPK) has a significant impact on cardiac gene expression, contractility, extracellular matrix remodeling, and inflammatory response in heart. The p38 kinase pathway also has a controversial role in cardiac hypertrophy. MAPK-activated protein kinase-2 (MK2) is a well-established p38 downstream kinase, yet its contribution to p38-mediated pathological response in heart has not been investigated.

Objective

We examined the specific contribution of MK2 to the pathological remodeling induced by p38.

Methods and results

We used a cardiomyocyte specific and inducible transgenic approach to determine the functional and molecular impact of acute activation of the p38 pathway in heart in either a MK2 wild-type or a M

SUBMITTER: Streicher JM 

PROVIDER: S-EPMC2903446 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature