Ethanol-regulated genes that contribute to ethanol sensitivity and rapid tolerance in Drosophila.

ABSTRACT:

Background

Increased ethanol intake, a major predictor for the development of alcohol use disorders, is facilitated by the development of tolerance to both the aversive and pleasurable effects of the drug. The molecular mechanisms underlying ethanol tolerance development are complex and are not yet well understood.

Methods

To identify genetic mechanisms that contribute to ethanol tolerance, we examined the time course of gene expression changes elicited by a single sedating dose of ethanol in Drosophila, and completed a behavioral survey of strains harboring mutations in ethanol-regulated genes.

Results

Enrichment for genes in metabolism, nucleic acid binding, olfaction, regulation of signal transduction, and stress suggests that these biological processes are coordin

SUBMITTER: Kong EC 

PROVIDER: S-EPMC2903447 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature