The ins and outs of nuclear trafficking: unusual aspects in apicomplexan parasites.

ABSTRACT: Apicomplexa is a phylum within the kingdom Protista that contains some of the most significant threats to public health. One of the members of this phylum, Toxoplasma gondii, is amenable to molecular genetic analyses allowing for the identification of factors critical for colonization and disease. A pathway found to be important for T. gondii pathogenesis is the Ran network of nuclear trafficking. Bioinformatics analysis of apicomplexan genomes shows that while Ran is well conserved, the key regulators of Ran--Regulator of Chromosome Condensation 1 and Ran GTPase activating protein--are either highly divergent or absent. Likewise, several import and export receptor molecules that are crucial for nuclear transport are either not present or have experienced genetic drift such that they are n

SUBMITTER: Frankel MB 

PROVIDER: S-EPMC2903460 | biostudies-literature | 2009 Jun

REPOSITORIES: biostudies-literature