Dynamic simulation of cardiolipin remodeling: greasing the wheels for an interpretative approach to lipidomics.

ABSTRACT: Cardiolipin is a class of mitochondrial specific phospholipid, which is intricately involved in mitochondrial functionality. Differences in cardiolipin species exist in a variety of tissues and diseases. It has been demonstrated that the cardiolipin profile is a key modulator of the functions of many mitochondrial proteins. However, the chemical mechanism(s) leading to normal and/or pathological distribution of cardiolipin species remain elusive. Herein, we describe a novel approach for investigating the molecular mechanism of cardiolipin remodeling through a dynamic simulation. This approach applied data from shotgun lipidomic analyses of the heart, liver, brain, and lung mitochondrial lipidomes to model cardiolipin remodeling, including relative content, regiospecificity, and isomeric co

SUBMITTER: Kiebish MA 

PROVIDER: S-EPMC2903823 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature