Construction of 5,6-Ring Fused 2-Pyridones: An Effective Annulation Tactic Achieved in Water.

ABSTRACT: An efficient protocol for elaboration of the 5,6-fused 2-pyridone ring system, exploiting the tandem condensation of propiolamide and cyclic β-ketomethyl esters in water, followed by acid or base promoted intramolecular ring closure and decarboxylation, has been developed.

SUBMITTER: Smith AB 

PROVIDER: S-EPMC2904244 | biostudies-literature | 2009 Jan

REPOSITORIES: biostudies-literature