LRP-1 promotes cancer cell invasion by supporting ERK and inhibiting JNK signaling pathways.

ABSTRACT:

Background

The low-density lipoprotein receptor-related protein-1 (LRP-1) is an endocytic receptor mediating the clearance of various extracellular molecules involved in the dissemination of cancer cells. LRP-1 thus appeared as an attractive receptor for targeting the invasive behavior of malignant cells. However, recent results suggest that LRP-1 may facilitate the development and growth of cancer metastases in vivo, but the precise contribution of the receptor during cancer progression remains to be elucidated. The lack of mechanistic insights into the intracellular signaling networks downstream of LRP-1 has prevented the understanding of its contribution towards cancer.

Methodology/principal findings

Through a short-hairpin RNA-mediated silencing approach, we identified L

SUBMITTER: Langlois B 

PROVIDER: S-EPMC2904376 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature