Altered gene expression in murine placentas in an infection-induced intrauterine growth restriction model: a microarray analysis.

ABSTRACT: The biological mechanisms leading to incomplete intrauterine growth are not completely elucidated and few studies have investigated infection-mediated growth restriction. In this investigation we report the alterations induced by maternal infectious challenge in placental gene expression patterns using a murine model. Pregnant dams were challenged at day E7.5 with the oral human pathogen Campylobacter rectus to elicit fetal growth restriction. At embryonic day E16.5 placentas were collected to compare placental gene expression patterns from normal fetuses of unchallenged dams and growth restricted fetuses from infected dams. Differential gene expression patterns were determined using Agilent Oligo array (G4121A) with a false discovery rate of P<0.05 and pathway analyses were performed. Sev

SUBMITTER: Bobetsis YA 

PROVIDER: S-EPMC2904600 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature