Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: a collaborative meta-analysis of 102 prospective studies.

ABSTRACT:

Background

Uncertainties persist about the magnitude of associations of diabetes mellitus and fasting glucose concentration with risk of coronary heart disease and major stroke subtypes. We aimed to quantify these associations for a wide range of circumstances.

Methods

We undertook a meta-analysis of individual records of diabetes, fasting blood glucose concentration, and other risk factors in people without initial vascular disease from studies in the Emerging Risk Factors Collaboration. We combined within-study regressions that were adjusted for age, sex, smoking, systolic blood pressure, and body-mass index to calculate hazard ratios (HRs) for vascular disease.

Findings

Analyses included data for 698 782 people (52 765 non-fatal or fatal vascular outcomes; 8.49 mil

SUBMITTER: Emerging Risk Factors Collaboration 

PROVIDER: S-EPMC2904878 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature