Electric field-driven disruption of a native beta-sheet protein conformation and generation of a helix-structure.

ABSTRACT: We demonstrate that an external constant electric field is able to modify the secondary structure of a protein and induce a transition from a beta-sheet into a helix-like conformation. This dramatic change is driven by a global rearrangement of the dipole moments at the amide planes. We also predict electric-field-induced modifications of the intermediate states of the protein.

SUBMITTER: Ojeda-May P 

PROVIDER: S-EPMC2905109 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature