Association of serum amyloid A protein and peptide fragments with prognosis in renal cancer.

ABSTRACT:

Background

In renal cell carcinoma (RCC), the discovery of biomarkers for clinical use is a priority. This study aimed to identify and validate diagnostic and prognostic serum markers using proteomic profiling.

Methods

Pre-operative sera from 119 patients with clear cell RCC and 69 healthy controls was analysed by surface-enhanced laser desorption/ionisation time-of-flight mass spectrometry with stringent in-house quality control and analysis routines. Following identification of one prognostic peak as a fragment of serum amyloid A (SAA), total serum SAA and CRP were also determined by immunoassay for further validation.

Results

Several peptides were identified as having independent prognostic but not diagnostic significance on multivariable analysis. One was subseque

SUBMITTER: Wood SL 

PROVIDER: S-EPMC2905280 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature