Osteosarcoma is characterised by reduced expression of markers of osteoclastogenesis and antigen presentation compared with normal bone.

ABSTRACT:

Background

Osteosarcoma (OS) is the most common primary bone tumour in children and adolescents. Patients who respond poorly to chemotherapy have a higher risk of metastatic disease and 5-year survival rates of only 10-20%. Therefore, identifying molecular targets that are specific for OS, or more specifically, metastatic OS, will be critical to the development of new treatment strategies to improve patient outcomes.

Methods

We performed a transcriptomic analysis of chemo-naive OS biopsies and non-malignant bone biopsies to identify differentially expressed genes specific to OS, which could provide insight into OS biology and chemoresistance.

Results

Statistical analysis of the OS transcriptomes found differential expression of several metallothionein family members,

SUBMITTER: Endo-Munoz L 

PROVIDER: S-EPMC2905286 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature