Characterization of a Clp protease gene regulator and the reaeration response in Mycobacterium tuberculosis.

ABSTRACT: Mycobacterium tuberculosis (MTB) enters a non-replicating state when exposed to low oxygen tension, a condition the bacillus encounters in granulomas during infection. Determining how mycobacteria enter and maintain this state is a major focus of research. However, from a public health standpoint the importance of latent TB is its ability to reactivate. The mechanism by which mycobacteria return to a replicating state upon re-exposure to favorable conditions is not understood. In this study, we utilized reaeration from a defined hypoxia model to characterize the adaptive response of MTB following a return to favorable growth conditions. Global transcriptional analysis identified the approximately 100 gene Reaeration Response, induced relative to both log-phase and hypoxic MTB. This respons

SUBMITTER: Sherrid AM 

PROVIDER: S-EPMC2905415 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature