Integrated profiling reveals a global correlation between epigenetic and genetic alterations in mesothelioma.

ABSTRACT: Development of mesothelioma is linked mainly to asbestos exposure, but the combined contributions of genetic and epigenetic alterations are unclear. We investigated the potential relationships between gene copy number (CN) alterations and DNA methylation profiles in a case series of pleural mesotheliomas (n = 23). There were no instances of significantly correlated CN alteration and methylation at probed loci, whereas averaging loci over their associated genes revealed only two genes with significantly correlated CN and methylation alterations. In contrast to the lack of discrete correlations, the overall extent of tumor CN alteration was significantly associated with DNA methylation profile when comparing CN alteration extent among methylation profile classes. Further, there was evidence

SUBMITTER: Christensen BC 

PROVIDER: S-EPMC2905466 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature