Disparate osteogenic response of mandible and iliac crest bone marrow stromal cells to pamidronate.

ABSTRACT:

Objective

Long-term administration of intravenous bisphosphonates like pamidronate is associated with jaw osteonecrosis but axial and appendicular bones remain unaffected. Pathogenesis of bisphosphonate-associated jaw osteonecrosis may relate to skeletal site-specific effects of bisphosphonates on osteogenic differentiation of bone marrow stromal cells (BMSCs) of orofacial and axial/appendicular bones. This study evaluated and compared skeletal site-specific osteogenic response of mandible (orofacial bone) and iliac crest (axial bone) human BMSCs to pamidronate.

Materials and methods

Mandible and iliac crest BMSCs from six normal healthy volunteers were established in culture and tested with pamidronate to evaluate and compare cell survival, osteogenic marker alkaline phosph

SUBMITTER: Stefanik D 

PROVIDER: S-EPMC2905679 | biostudies-literature | 2008 Jul

REPOSITORIES: biostudies-literature