Serial MRI and CSF biomarkers in normal aging, MCI, and AD.

ABSTRACT:

Objective

To compare the annual change in MRI and CSF biomarkers in cognitively normal (CN), amnestic mild cognitive impairment (aMCI), and Alzheimer disease (AD). Comparisons were based on intergroup discrimination, correlation with concurrent cognitive/functional changes, relationships to APOE genotype, and sample sizes for clinical trials.

Methods

We used data from the Alzheimer's Disease Neuroimaging Initiative study consisting of CN, aMCI, and AD cohorts with both baseline and 12-month follow-up CSF and MRI. The annual change in CSF (total-tau [t-tau], Abeta(1-42)) and MRI (change in ventricular volume) was obtained in 312 subjects (92 CN, 149 aMCI, 71 AD).

Results

There was no significant average annual change in either CSF biomarker in any clinical group except

SUBMITTER: Vemuri P 

PROVIDER: S-EPMC2905929 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature