Temporal course of depressive symptoms during the development of Alzheimer disease.

ABSTRACT:

Objective

To characterize change in depressive symptoms before and after the onset of dementia in Alzheimer disease (AD).

Method

We used data from the Chicago Health and Aging Project, a longitudinal cohort study of risk factors for AD in a geographically defined population of old people. Two subsets were analyzed. In 357 individuals who developed incident AD during the study, self-report of depressive symptoms (Center for Epidemiologic Studies Depression Scale) was obtained at 3-year intervals for a mean of 8 to 9 years. In 340 individuals who agreed to annual data collection, informant report of depressive symptoms (Hamilton Depression Rating Scale) was obtained for a mean of 3 years after a diagnosis of AD (n = 107), mild cognitive impairment (n = 81), or no cognitive imp

SUBMITTER: Wilson RS 

PROVIDER: S-EPMC2906401 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature