Prediction of protein-protein interactions in dengue virus coat proteins guided by low resolution cryoEM structures.

ABSTRACT:

Background

Dengue virus along with the other members of the flaviviridae family has reemerged as deadly human pathogens. Understanding the mechanistic details of these infections can be highly rewarding in developing effective antivirals. During maturation of the virus inside the host cell, the coat proteins E and M undergo conformational changes, altering the morphology of the viral coat. However, due to low resolution nature of the available 3-D structures of viral assemblies, the atomic details of these changes are still elusive.

Results

In the present analysis, starting from Calpha positions of low resolution cryo electron microscopic structures the residue level details of protein-protein interaction interfaces of dengue virus coat proteins have been predicted. By compa

SUBMITTER: Gadkari RA 

PROVIDER: S-EPMC2906493 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature