Human antibodies reveal a protective epitope that is highly conserved among human and nonhuman influenza A viruses.

ABSTRACT: Influenza remains a serious public health threat throughout the world. Vaccines and antivirals are available that can provide protection from infection. However, new viral strains emerge continuously because of the plasticity of the influenza genome, which necessitates annual reformulation of vaccine antigens, and resistance to antivirals can appear rapidly and become entrenched in circulating virus populations. In addition, the spread of new pandemic strains is difficult to contain because of the time required to engineer and manufacture effective vaccines. Monoclonal antibodies that target highly conserved viral epitopes might offer an alternative protection paradigm. Herein we describe the isolation of a panel of monoclonal antibodies derived from the IgG(+) memory B cells of healthy, h

SUBMITTER: Grandea AG 

PROVIDER: S-EPMC2906546 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature