Efficacy of methotrexate in ulcerative colitis: failure or promise.

ABSTRACT:

Background

Low-dose methotrexate is a widely used and efficacious therapy in chronic inflammatory disorders such as psoriasis and rheumatoid arthritis. Prospective randomized controlled trials have demonstrated the efficacy of parenteral methotrexate in Crohn's disease (CD). We performed a systematic review of the efficacy of methotrexate in ulcerative colitis (UC) and discuss the results in the context of the known pharmacokinetics and adverse events of methotrexate therapy in inflammatory bowel diseases and other inflammatory conditions.

Materials and methods

We performed a systematic review of the literature in Medline, Embase, and Web of Science. All publications describing patients with UC treated with methotrexate were included.

Results

We identified 12 studies

SUBMITTER: Herfarth HH 

PROVIDER: S-EPMC2906638 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature