Ten common genetic variants associated with colorectal cancer risk are not associated with survival after diagnosis.

ABSTRACT:

Purpose

To date, genomewide association studies have identified 10 genetic loci associated with colorectal cancer (CRC) susceptibility. We hypothesized that these loci might also affect cancer survival.

Experimental design

To determine whether single-nucleotide polymorphisms tagging these 10 loci influenced all-cause and CRC-specific mortality, we prospectively followed survival outcomes for 2,838 Scottish patients recruited soon after a diagnosis of CRC. Survival analysis was conducted using Cox proportional hazard models adjusted for American Joint Committee on Cancer stage, age, and sex.

Results

None of the single-nucleotide polymorphisms were found to be statistically significantly associated with all-cause or CRC-specific mortality.

Conclusions

We conclude

SUBMITTER: Tenesa A 

PROVIDER: S-EPMC2906703 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature