Interictal EEG spikes identify the region of electrographic seizure onset in some, but not all, pediatric epilepsy patients.

ABSTRACT:

Purpose

The role of sharps and spikes, interictal epileptiform discharges (IEDs), in guiding epilepsy surgery in children remains controversial, particularly with intracranial electroencephalography (IEEG). Although ictal recording is the mainstay of localizing epileptic networks for surgical resection, current practice dictates removing regions generating frequent IEDs if they are near the ictal onset zone. Indeed, past studies suggest an inconsistent relationship between IED and seizure-onset location, although these studies were based upon relatively short EEG epochs.

Methods

We employ a previously validated, computerized spike detector to measure and localize IED activity over prolonged, representative segments of IEEG recorded from 19 children with intractable, mostly e

SUBMITTER: Marsh ED 

PROVIDER: S-EPMC2907216 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature