TRPM7-mediated Ca2+ signals confer fibrogenesis in human atrial fibrillation.

ABSTRACT:

Rationale

Cardiac fibrosis contributes to pathogenesis of atrial fibrillation (AF), which is the most commonly sustained arrhythmia and a major cause of morbidity and mortality. Although it has been suggested that Ca(2+) signals are involved in fibrosis promotion, the molecular basis of Ca(2+) signaling mechanisms and how Ca(2+) signals contribute to fibrogenesis remain unknown.

Objective

To determine the molecular mechanisms of Ca(2+)-permeable channel(s) in human atrial fibroblasts, and to investigate how Ca(2+) signals contribute to fibrogenesis in human AF.

Methods and results

We demonstrate that the transient receptor potential (TRP) melastatin related 7 (TRPM7) is the molecular basis of the major Ca(2+)-permeable channel in human atrial fibroblasts. Endogenous T

SUBMITTER: Du J 

PROVIDER: S-EPMC2907241 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature