Collateral capillary arterialization following arteriolar ligation in murine skeletal muscle.

ABSTRACT:

Objective

Chronic and acute ischemic diseases-peripheral artery disease, coronary artery disease, stroke-result in tissue damage unless blood flow is maintained or restored in a timely manner. Mice of different strains recover from arteriolar ligation (by increasing collateral blood flow) at different speeds. We quantify the spatio-temporal patterns of microvascular network remodeling following arteriolar ligation in different mouse strains to better understand inter-individual variability.

Methods

Whole-muscle spinotrapezius microvascular networks of mouse strains C57Bl/6, Balb/c and CD1 were imaged using confocal microscopy following ligation of feeding arterioles.

Results

Baseline arteriolar structures of C57Bl/6 and Balb/c mice feature heavily ramified arcades and

SUBMITTER: Mac Gabhann F 

PROVIDER: S-EPMC2907254 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature