Nuclear localization of orphan receptor protein kinase (Ror1) is mediated through the juxtamembrane domain.

ABSTRACT:

Background

Several receptor tyrosine kinases (RTKs) such as EGFR, FGFR, TRK, and VEGFR are capable of localizing in the cell nucleus in addition to their usual plasma membrane localization. Recent reports also demonstrate that nuclear-localized RTKs have important cellular functions such as transcriptional activation. On the basis of preliminary bioinformatic analysis, additional RTKs, including receptor tyrosine kinase-like orphan receptor 1 (Ror1) were predicted to have the potential for nuclear subcellular localization. Ror1 is a receptor protein tyrosine kinase that modulates neurite growth in the central nervous system. Because the nuclear localization capability of the Ror1 cytoplasmic domain has not been reported, we examined the cellular expression distribution of this regi

SUBMITTER: Tseng HC 

PROVIDER: S-EPMC2907318 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature