Assessing the impact of a combined analysis of four common low-risk genetic variants on autism risk.

ABSTRACT:

Background

Autism is a complex disorder characterized by deficits involving communication, social interaction, and repetitive and restrictive patterns of behavior. Twin studies have shown that autism is strongly heritable, suggesting a strong genetic component. In other disease states with a complex etiology, such as type 2 diabetes, cancer and cardiovascular disease, combined analysis of multiple genetic variants in a genetic score has helped to identify individuals at high risk of disease. Genetic scores are designed to test for association of genetic markers with disease.

Method

The accumulation of multiple risk alleles markedly increases the risk of being affected, and compared with studying polymorphisms individually, it improves the identification of subgroups of indiv

SUBMITTER: Carayol J 

PROVIDER: S-EPMC2907567 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature