An outbreak of aseptic meningitis caused by coxsackievirus A9 in Gansu, the People's Republic of China.

ABSTRACT:

Background

An outbreak of aseptic meningitis occurred in Tianshui city of Gansu Province, the People's Republic of China, from March to June 2005. A total of 85 patients were clinical confirmed as aseptic meningitis in this outbreak.

Results

CVA9 was mainly responsible for this outbreak supported by the clinical manifestations of the patients, epidemiological data of the outbreak, the results of RT-PCR and complete VP1 sequence determination, conventional neutralization assays, IgM serological assays, viral isolation and phylogenetics analysis. Through phylogenetic analysis and homogeneity analysis for partial VP1 gene, the nucleotide and amino acid homologies between Gansu isolates and former Chinese CVA9 strains were 88.2%-96.1% and 97.2%-99.2%, respectively. Multiple tran

SUBMITTER: Cui A 

PROVIDER: S-EPMC2907575 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature