A general strategy for the preparation of C-terminal peptide alpha-ketoacids by solid phase peptide synthesis.

ABSTRACT: A new cyanosulfur-ylide based linker makes possible the synthesis of C-terminal peptide alpha-ketoacids by solid phase synthesis. The preparation of the requisite linker and its application to a variety of C-terminal peptide alpha-ketoacids with unprotected side chains is reported.

SUBMITTER: Ju L 

PROVIDER: S-EPMC2907649 | biostudies-literature | 2009 Jun

REPOSITORIES: biostudies-literature