The steady-state transcriptome of the four major life-cycle stages of Trypanosoma cruzi.

ABSTRACT:

Background

Chronic chagasic cardiomyopathy is a debilitating and frequently fatal outcome of human infection with the protozoan parasite, Trypanosoma cruzi. Microarray analysis of gene expression during the T. cruzi life-cycle could be a valuable means of identifying drug and vaccine targets based on their appropriate expression patterns, but results from previous microarray studies in T. cruzi and related kinetoplastid parasites have suggested that the transcript abundances of most genes in these organisms do not vary significantly between life-cycle stages.

Results

In this study, we used whole genome, oligonucleotide microarrays to globally determine the extent to which T. cruzi regulates mRNA relative abundances over the course of its complete life-cycle. In contrast to p

SUBMITTER: Minning TA 

PROVIDER: S-EPMC2907688 | biostudies-literature | 2009 Aug

REPOSITORIES: biostudies-literature