Upregulation of FOXM1 induces genomic instability in human epidermal keratinocytes.

ABSTRACT:

Background

The human cell cycle transcription factor FOXM1 is known to play a key role in regulating timely mitotic progression and accurate chromosomal segregation during cell division. Deregulation of FOXM1 has been linked to a majority of human cancers. We previously showed that FOXM1 was upregulated in basal cell carcinoma and recently reported that upregulation of FOXM1 precedes malignancy in a number of solid human cancer types including oral, oesophagus, lung, breast, kidney, bladder and uterus. This indicates that upregulation of FOXM1 may be an early molecular signal required for aberrant cell cycle and cancer initiation.

Results

The present study investigated the putative early mechanism of UVB and FOXM1 in skin cancer initiation. We have demonstrated that UVB dose

SUBMITTER: Teh MT 

PROVIDER: S-EPMC2907729 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature