Two-component approach toward a fully substituted N-fused pyrrole ring.

ABSTRACT: An efficient two-component palladium-catalyzed arylation/cyclization cascade approach toward a variety of N-fused pyrroloheterocycles has been developed. This transformation proceeds via the palladium-catalyzed coupling of aryl halides with propargylic esters or ethers followed by the 5-endo-dig cyclization leading to highly functionalized pyrroloheterocycles in good to excellent yield.

SUBMITTER: Chernyak D 

PROVIDER: S-EPMC2908008 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature