Population based allele frequencies of disease associated polymorphisms in the Personalized Medicine Research Project.

ABSTRACT:

Background

There is a lack of knowledge regarding the frequency of disease associated polymorphisms in populations and population attributable risk for many populations remains unknown. Factors that could affect the association of the allele with disease, either positively or negatively, such as race, ethnicity, and gender, may not be possible to determine without population based allele frequencies.Here we used a panel of 51 polymorphisms previously associated with at least one disease and determined the allele frequencies within the entire Personalized Medicine Research Project population based cohort. We compared these allele frequencies to those in dbSNP and other data sources stratified by race. Differences in allele frequencies between self reported race, region of origin, an

SUBMITTER: Cross DS 

PROVIDER: S-EPMC2908055 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature