Pathway analysis comparison using Crohn's disease genome wide association studies.

ABSTRACT:

Background

The use of biological annotation such as genes and pathways in the analysis of gene expression data has aided the identification of genes for follow-up studies and suggested functional information to uncharacterized genes. Several studies have applied similar methods to genome wide association studies and identified a number of disease related pathways. However, many questions remain on how to best approach this problem, such as whether there is a need to obtain a score to summarize association evidence at the gene level, and whether a pathway, dominated by just a few highly significant genes, is of interest.

Methods

We evaluated the performance of two pathway-based methods (Random Set, and Binomial approximation to the hypergeometric test) based on their applicat

SUBMITTER: Ballard D 

PROVIDER: S-EPMC2908056 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature