Alterations in LMTK2, MSMB and HNF1B gene expression are associated with the development of prostate cancer.

ABSTRACT:

Background

Genome wide association studies (GWAS) have identified several genetic variants that are associated with prostate cancer. Most of these variants, like other GWAS association signals, are located in non-coding regions of potential candidate genes, and thus could act at the level of the mRNA transcript.

Methods

We measured the expression and isoform usage of seven prostate cancer candidate genes in benign and malignant prostate by real-time PCR, and correlated these factors with cancer status and genotype at the GWAS risk variants.

Results

We determined that levels of LMTK2 transcripts in prostate adenocarcinomas were only 32% of those in benign tissues (p = 3.2 x 10(-7)), and that an independent effect of genotype at variant rs6465657 on LMTK2 expression in

SUBMITTER: Harries LW 

PROVIDER: S-EPMC2908099 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature