A systematic review of models to predict recruitment to multicentre clinical trials.

ABSTRACT:

Background

Less than one third of publicly funded trials managed to recruit according to their original plan often resulting in request for additional funding and/or time extensions. The aim was to identify models which might be useful to a major public funder of randomised controlled trials when estimating likely time requirements for recruiting trial participants. The requirements of a useful model were identified as usability, based on experience, able to reflect time trends, accounting for centre recruitment and contribution to a commissioning decision.

Methods

A systematic review of English language articles using MEDLINE and EMBASE. Search terms included: randomised controlled trial, patient, accrual, predict, enroll, models, statistical; Bayes Theorem; Decision Theory

SUBMITTER: Barnard KD 

PROVIDER: S-EPMC2908107 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature