Synthetic heparan sulfate oligosaccharides inhibit endothelial cell functions essential for angiogenesis.

ABSTRACT:

Background

Heparan sulfate (HS) is an important regulator of the assembly and activity of various angiogenic signalling complexes. However, the significance of precisely defined HS structures in regulating cytokine-dependent angiogenic cellular functions and signalling through receptors regulating angiogenic responses remains unclear. Understanding such structure-activity relationships is important for the rational design of HS fragments that inhibit HS-dependent angiogenic signalling complexes.

Methodology/principal findings

We synthesized a series of HS oligosaccharides ranging from 7 to 12 saccharide residues that contained a repeating disaccharide unit consisting of iduronate 2-O-sulfate linked to glucosamine with or without N-sulfate. The ability of oligosaccharides to

SUBMITTER: Cole CL 

PROVIDER: S-EPMC2908126 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature