FoxO and stress responses in the cnidarian Hydra vulgaris.

ABSTRACT:

Background

In the face of changing environmental conditions, the mechanisms underlying stress responses in diverse organisms are of increasing interest. In vertebrates, Drosophila, and Caenorhabditis elegans, FoxO transcription factors mediate cellular responses to stress, including oxidative stress and dietary restriction. Although FoxO genes have been identified in early-arising animal lineages including sponges and cnidarians, little is known about their roles in these organisms.

Methods/principal findings

We have examined the regulation of FoxO activity in members of the well-studied cnidarian genus Hydra. We find that Hydra FoxO is expressed at high levels in cells of the interstitial lineage, a cell lineage that includes multipotent stem cells that give rise to neurons

SUBMITTER: Bridge D 

PROVIDER: S-EPMC2908143 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature