Neurod1 suppresses hair cell differentiation in ear ganglia and regulates hair cell subtype development in the cochlea.

ABSTRACT:

Background

At least five bHLH genes regulate cell fate determination and differentiation of sensory neurons, hair cells and supporting cells in the mammalian inner ear. Cross-regulation of Atoh1 and Neurog1 results in hair cell changes in Neurog1 null mice although the nature and mechanism of the cross-regulation has not yet been determined. Neurod1, regulated by both Neurog1 and Atoh1, could be the mediator of this cross-regulation.

Methodology/principal findings

We used Tg(Pax2-Cre) to conditionally delete Neurod1 in the inner ear. Our data demonstrate for the first time that the absence of Neurod1 results in formation of hair cells within the inner ear sensory ganglia. Three cell types, neural crest derived Schwann cells and mesenchyme derived fibroblasts (neither express

SUBMITTER: Jahan I 

PROVIDER: S-EPMC2908541 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature