Plasmodium vivax circumsporozoite genotypes: a limited variation or new subspecies with major biological consequences?

ABSTRACT:

Background

Plasmodium vivax circumsporozoite variants have been identified in several geographical areas. The real implication of the genetic variation in this region of the P. vivax genome has been questioned for a long time. Although previous studies have observed significant association between VK210 and the Duffy blood group, we present here that evidences of this variation are limited to the CSP central portion.

Methods

The phylogenetic analyses were accomplished starting from the amplification of conserved domains of 18 SSU RNAr and Cyt B. The antibodies responses against the CSP peptides, MSP-1, AMA-1 and DBP were detected by ELISA, in plasma samples of individuals infected with two P. vivax CS genotypes: VK210 and P. vivax-like.

Results

These analyses of the t

SUBMITTER: Souza-Neiras WC 

PROVIDER: S-EPMC2908638 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature