Beta-cell function declines within the first year postpartum in women with recent glucose intolerance in pregnancy.

ABSTRACT:

Objective

Both gestational diabetes mellitus (GDM) and mild glucose intolerance in pregnancy identify women at increased risk of future type 2 diabetes. In this context, we queried whether metabolic changes that occur in the 1st year postpartum vary in relation to gestational glucose tolerance status.

Research design and methods

Three-hundred-and-ninety-two women underwent glucose challenge test (GCT) and oral glucose tolerance test (OGTT) in pregnancy followed by repeat OGTT at both 3 months' postpartum and 12 months' postpartum. The antepartum testing defined four gestational glucose tolerance groups: GDM (n = 107); gestational impaired glucose tolerance (GIGT) (n = 75); abnormal GCT with normal glucose tolerance (NGT) on OGTT (abnormal GCT NGT) (n = 137); and normal GCT w

SUBMITTER: Retnakaran R 

PROVIDER: S-EPMC2909065 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature